PIANO - Imaging and Therapy of Chronic Pain in the Dorsal Root Ganglia (DRG)

Chronic pain is a debilitating disease, which affects approximately 1.5 billion people worldwide, and of those, approximately 4% suffer from neuropathic pain. Neuropathic pain is often described as a shooting or burning pain that can come and then disappear but equally it may become chronic, where the pain may become unrelenting and severe. It often is the result of nerve damage or a malfunctioning nervous system. Additionally there is the impact upon society where the costs related to disability allowance, treatment, lost wages and productivity impacts the economy. Current treatments for chronic pain are not fully reliable and there is a severe lack of tools to diagnose or visualise the pain process within the dorsal root ganglia (DRG). Humans have 62 DRGs which are the first relay stations in the pain pathway. Local targeted treatment at the level of those DRGs involved in the pain process is the solution to circumvent side effects and optimise treatment. 
We aim to identify involved DRGs by visualising cells or molecules in the DRG which are directly or indirectly associated with the generation of pain. We will use a novel method of nanoparticles targeted towards pain-associated cells or molecules in the DRG. A vast amount of neuropathic pain studies have shown an eminent infiltration of macrophages into affected DRGs. These nanoparticles will be specifically designed to target initially the macrophages in the DRG, encapsulating both therapeutic payloads and imaging contrast reagents to monitor pain-associated activities. The goal of PIANO is therefore to facilitate a state-of-art approach to visualisation of neuropathic pain / inflammation at DRG sites as well as to simultaneously release analgesic molecules from the nanoparticles.

https://cordis.europa.eu/project/id/956477

Start Date: 01/03/2021 – End Date: 28/02/2025  

Totale finanziamento: € 4.093.424,64

Budget quota UNICAM: € 522.999,36

 

Acronimo: 
PIANO
Soggetto finanziatore: 
European Union
Programma di Finanziamento e bando: 
H2020-MSCA-ITN-2020
Numero del progetto/Contratto: 
956477
Responsabile Scientifico: 
Prof.ssa Piera Di Martino
ruolo Unicam: 
Partner
Partner: 
Nome: 
KING'S COLLEGE LONDON
Tipologia: 
University
Stato: 
UK
Ruolo: 
Coordinator
Nome: 
ACADEMISCH ZIEKENHUIS LEIDEN
Tipologia: 
University
Stato: 
Olanda
Ruolo: 
Partner
Nome: 
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Tipologia: 
University
Stato: 
Italy
Ruolo: 
Partner
Nome: 
PERCUROS BV
Tipologia: 
Ente Privato - Profit
Stato: 
Olanda
Ruolo: 
Partner
Nome: 
UNIVERSITY OF LEEDS
Tipologia: 
University
Stato: 
UK
Ruolo: 
Partner
Nome: 
THE UNIVERSITY OF EDINBURGH
Tipologia: 
University
Stato: 
UK
Ruolo: 
Partner
Nome: 
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Tipologia: 
University
Stato: 
Spagna
Ruolo: 
Partner
Nome: 
MEDRES-MEDICAL RESEARCH GMBH
Tipologia: 
Ente Privato - Profit
Stato: 
Germania
Ruolo: 
Partner
Nome: 
POLYPURE AS
Tipologia: 
Ente Privato - Profit
Stato: 
Norvegia
Ruolo: 
Partner
Nome: 
CHEMPRECISE CONSULTORIA BIOTECNOLOGIA PRODUTOS FARMACEUTICOS E IMOBILIARIO LDA
Tipologia: 
Ente Privato - Profit
Stato: 
Portogallo
Ruolo: 
Partner
Tipo di finanziamento: 
Horizon 2020